The Planning Committee has approved plans for Dandara to redevelop part of the Hotel de France complex to create new apartments.
The hotel's south wing, upper parking structure and staff accommodation will be demolished.
The plans from architects, Axis Mason, are for 62 one-bedroom and 62 two-bedroom apartments, including parking and new vehicle access from Wellington Road.
The hotel site dates back to the 1800s, but opened as the Hotel de France in 1954.